Monitor Intently (1)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Mitotane is actually a strong inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for achievable dosage adjustments.Inform sufferers not to function motor motor vehicle